GEMINIMAB ADC PLATFORM

GeminiMab™ is the first and only platform that allows for hinge-region Cys229 site-specific conjugation of native antibodies, enabling unprecedented simplicity and scope in creating efficient and well-tolerated antibody conjugates (ADC), including unique DAR1 ADC.

This process eliminates the need for enzymes, antibody sequence modification, or specific pretargeting units to achieve site specificity. The resulting conjugates preserve both the native glycation profile and the covalent linkage between antibody chains.

Syndivia leverages GeminiMab™ Technology to develop ADC with optimized DAR to achieve the highest dosing without compromising safety, attributable to improved tumor penetration and enhanced therapeutic efficacy.

Accessing optimal DAR with GeminiMab™

For any payload family, in a site-specific manner, to achieve maximum efficacy.

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    3. Lehot, V. et al. Reinvestigation of the Automated Synthesis of Stoichiometrically Conjugated Antibodies to Access High Molecular Weight Payloads and Multiplexed Conjugation via an In-Solution Trans-Tagging Process. ACS Omega 8, 40508–40516 (2023).

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    5. Dovgan, I. et al. Automated linkage of proteins and payloads producing monodisperse conjugates. Chem Sci 11, 1210–1215 (2020).

    6. Dovgan, I. et al. On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency. Sci Rep 10, 7691 (2020).

    7. Dovgan, I., Koniev, O., Kolodych, S. & Wagner, A. Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents. Bioconjug Chem 30, 2483–2501 (2019).

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    12. Kolodych, S. et al. Development and evaluation of β-galactosidase-sensitive antibody-drug conjugates. Eur J Med Chem 142, 376–382 (2017).

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    15. Dovgan, I., Kolodych, S., Koniev, O. & Wagner, A. 2-(Maleimidomethyl)-1,3-Dioxanes (MD): a Serum-Stable Self-hydrolysable Hydrophilic Alternative to Classical Maleimide Conjugation. Sci Rep 6, 30835 (2016).

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    17. Kolodych, S. et al. CBTF: New Amine-to-Thiol Coupling Reagent for Preparation of Antibody Conjugates with Increased Plasma Stability. Bioconjug Chem 26, 197–200 (2015).

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    • Syndivia actively protects its innovative products and technologies, especially focusing on the DAR1 antibody-drug conjugate platform and conjugation technologies. We achieve this by patenting our products and processes and obtaining exclusive licenses from top academic and research institutions.

    • Our strategy is built on using our in-house expertise, continuously innovating, and strategically licensing technologies to maintain our unique market position. We strive to secure patents both in our home country and internationally, always looking to expand our intellectual property portfolio.

    • Our IP portfolio includes five main patent families, specifically targeting our DAR1 platform and conjugation technologies. This encompasses patents we own ourselves and those we have exclusively licensed from research institutions, providing strong protection for our core technologies.